A novel strategy for bitter taste masking of gankeshuangqing dispersible tablets based on particle coating technology

A Novel Strategy for Bitter Taste Masking of Gankeshuangqing Dispersible Tablets Based on Particle Coating Technology

BACKGROUND Currently, acute upper respiratory tract infections (AURTIs) are increasingly becoming a significant health burden. Gankeshuangqing dispersible tablets (GKSQDT) which have a good effect on treating AURTIs. GKSQDT is composed of baicalin and andrographolide. However, its severe bitterness limits application of patients. Due to the addition of plentiful accessories, common masking meth...

Particle Coating, Taste Masking & Pelletization

Formulation and Evaluation of Taste Masked Dispersible Tablets of Zidovudine

Zidovudine is an antiretroviral drug commonly used in the treatment HIV infection. But it is very bitter in taste and sparingly soluble in water. Thus the purpose of this investigation was to formulate and evaluate taste masked dispersible tablets of zidovudine. Dispersible tablets of zidovudine were prepared using crosscarmellose sodium (Ac-di-sol) as disintegrant. Surelease clear (E-7-19010) ...

Design and optimization of artemether microparticles for bitter taste masking.

The objective of the present investigation was to reduce the bitterness of artemether (ARM). Microparticles were prepared by the coacervation method using Eudragit E 100 (EE) as polymer and sodium hydroxide solution as nonsolvent for the polymer. A 32 full factorial design was used for optimization wherein the amount of drug (A) and polymer (B) were selected as independent variables and the bit...

Prodrugs for Masking the Bitter Taste of Drugs